Lithium Carbonate → HCID 59273010, compound

HRID 907036Notes

Reaction equation

HRID 907036 reaction equation
C1([C@:4]2([OH:12])[CH2:8][CH2:7][NH:6][C@H:5]2[CH:9](C)C)CC1.[F:13][C:14]1[C:21]([CH3:22])=[C:20](F)[CH:19]=[CH:18][C:15]=1[C:16]#[N:17].[C:24](=O)([O-])[O-].[Li+].[Li+]>>[F:13][C:14]1[C:21]([CH3:22])=[C:20]([N:6]2[C@H:7]([CH3:24])[CH2:8][C@H:4]([OH:12])[C@@H:5]2[CH3:9])[CH:19]=[CH:18][C:15]=1[C:16]#[N:17]

Participants

4

Reactant 3

HCID 11125Lithium CarbonateHCID 113441192,4-Difluoro-3-methylbenzonitrileHCID 59273011(2S,3R)-3-cyclopropyl-2-isopropylpyrrolidin-3-ol

Product 1

HCID 59273010HCID 59273010, compound

Procedure

By an operation in the same manner as in Example 53 and using (2S,3S,5R)-2,5-dimethylpyrrolidin-3-ol 0.5 oxalate (189 mg), 2,4-difluoro-3-methylbenzonitrile (510 mg) and lithium carbonate (200 mg), the title compound was obtained as colorless oil (yield: 20 mg, yield: 6.8%).

Sources & evidence

ORD record
ord-e557f70f02a74c80a23690c68d18c4d6
Source dataset
uspto-grants-2011_09
Patent number
US08013008B2

Reaction notes

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