Lithium Carbonate → HCID 59273027, compound

Participants

Reaction Steps

By an operation in the same manner as in Reference Example 51 and using benzyl (2S,3S,5R)-3-hydroxy-2,3,5-trimethylpyrrolidine-1-carboxylate (450 mg), 10% palladium carbon (50% water-containing, 40 mg) and oxalic acid (77 mg), (2S,3S,5R)-2,3,5-trimethylpyrrolidin-3-ol 0.5 oxalate was obtained as a colorless solid (yield: 285.3 mg, yield: 96%). By an operation in the same manner as in Reference Example 53 and using (2S,3S,5R)-2,3,5-trimethylpyrrolidin-3-ol 0.5 oxalate (50 mg), 2-chloro-4-fluorobenzonitrile (67 mg) and lithium carbonate (46.7 mg), the title compound was obtained as a colorless solid (yield: 36.3 mg, yield: 48%).

Provenance & Evidence