Lithium Carbonate → HCID 59273019, compound

HRID 907038Notes

Reaction equation

[CH:1]1([C@:4]2([OH:12])[CH2:8][CH2:7][NH:6][C@H:5]2[CH:9](C)C)CC1.[F:13][C:14]1[CH:21]=[C:20](F)[CH:19]=[CH:18][C:15]=1[C:16]#[N:17].[C:23](=O)([O-])[O-].[Li+].[Li+]>>[F:13][C:14]1[CH:21]=[C:20]([N:6]2[C@H:7]([CH3:23])[CH2:8][C@@:4]([OH:12])([CH3:1])[C@@H:5]2[CH3:9])[CH:19]=[CH:18][C:15]=1[C:16]#[N:17]

Participants

Reactant 3

HCID 11125Lithium Carbonate

HCID 775452,4-Difluorobenzonitrile

HCID 59273011(2S,3R)-3-cyclopropyl-2-isopropylpyrrolidin-3-ol

Product 1

HCID 59273019HCID 59273019, compound

Procedure

By an operation in the same manner as in Example 53 and using (2S,3S,5R)-2,3,5-trimethylpyrrolidin-3-ol 0.5 oxalate (93 mg), 2,4-difluorobenzonitrile (120 mg) and lithium carbonate (93 mg), the title compound was obtained as a colorless solid (yield: 76 mg, yield: 57%).

Sources & evidence

ORD record: ord-77d24b06f2794044b54bc9dcccf11b6e
Source dataset: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08013008B2

Reaction notes

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