(Pyridin-4-yl)boronic acid → HCID 67396869, compound

HRID 907062Notes

Reaction equation

HRID 907062 reaction equation
[C:1]([O:4][C@@H:5]1[C@@H:20]([O:21][C:22](=[O:24])[CH3:23])[C@H:19]([O:25][C:26](=[O:28])[CH3:27])[CH2:18][S:17][C@H:6]1[O:7][C:8]1[CH:13]=[C:12](Br)[CH:11]=[C:10]([F:15])[C:9]=1[F:16])(=[O:3])[CH3:2].[N:29]1[CH:34]=[CH:33][C:32](B(O)O)=[CH:31][CH:30]=1>>[C:1]([O:4][C@@H:5]1[C@@H:20]([O:21][C:22](=[O:24])[CH3:23])[C@H:19]([O:25][C:26](=[O:28])[CH3:27])[CH2:18][S:17][C@H:6]1[O:7][C:8]1[CH:13]=[C:12]([C:32]2[CH:33]=[CH:34][N:29]=[CH:30][CH:31]=2)[CH:11]=[C:10]([F:15])[C:9]=1[F:16])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 2734379(Pyridin-4-yl)boronic acidHCID 67397355HCID 67397355, compound

Product 1

HCID 67396869HCID 67396869, compoundYield 81%

Procedure

By carrying out the operation analogously to example 3, starting from 5-bromo-2,3-difluorophenyl 2,3,4-tri-O-acetyl-5-thio-β-D-xylopyranoside, obtained according to preparation VIII, and 4-pyridineboronic acid, the expected product is obtained in the form of a white powder with a yield of 81%.

Workup

  1. customobtained

Sources & evidence

ORD record
ord-971fda9b05314e3e91b9fdf1daa7c7e0
Source dataset
uspto-grants-2011_09
Patent number
US08013010B2

Reaction notes

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