3,5-Dimethylisoxazole-4-boronic acid → HCID 67397883, compound

HRID 907072Notes

Reaction equation

HRID 907072 reaction equation
C([O:4][C@@H:5]1[C@@H:18]([O:19]C(=O)C)[C@H:17]([O:23]C(=O)C)[CH2:16][S:15][C@H:6]1[O:7][C:8]1[CH:13]=[CH:12][C:11](I)=[CH:10][CH:9]=1)(=O)C.[CH3:27][C:28]1[C:32](B(O)O)=[C:31]([CH3:36])[O:30][N:29]=1>>[O:7]([C:8]1[CH:9]=[CH:10][C:11]([C:32]2[C:28]([CH3:27])=[N:29][O:30][C:31]=2[CH3:36])=[CH:12][CH:13]=1)[C@@H:6]1[S:15][CH2:16][C@@H:17]([OH:23])[C@H:18]([OH:19])[C@H:5]1[OH:4]

Participants

3

Reactant 2

HCID 27343463,5-Dimethylisoxazole-4-boronic acidHCID 67396128HCID 67396128, compound

Product 1

HCID 67397883HCID 67397883, compoundYield 63%

Procedure

By carrying out the operation analogously to example 29, starting from 4-iodophenyl 2,3,4-tri-O-acetyl-5-thio-β-D-xylopyranoside, obtained according to preparation II, and 3,5-dimethyl-4-isoxazoleboronic acid, the expected compound is obtained in the form of a white solid with a yield of 63%.

Workup

  1. customobtained

Sources & evidence

ORD record
ord-a39d203c3e104a34897e46240d3b4997
Source dataset
uspto-grants-2011_09
Patent number
US08013010B2

Reaction notes

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