HuagongsheHuagongshe Chemistry Print Report · For research reference only
Boron tribromide → HCID 59425169, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Boron tribromide | HCID 25134 | — |
| Reactant | HCID 11589308 | HCID 11589308 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 59425169 | HCID 59425169 | — |
Reaction Steps
Following the procedure in example 1B step A, 2-[4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)phenyl]-1-ethyl-6-methoxy-1H-indole-3-carbonitrile was treated with 1M BBr3 solution in CH2Cl2 at −15° C. for 1.5 h and then poured into ice-water and filtered and dried to afford 2-[4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)phenyl]-1-ethyl-6-hydroxy-1H-indole-3-carbonitrile in nearly quantitative yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08013006B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-7196f559912a44a0ab1c43a528c86637 |
| Source note | uspto-grants-2011_09 |