反应详情

4-Bromomethylbenzoyl bromide (13.9 g, 50 mmol, 1.0 eq) was added to 50 mL of DCM, followed by t-butanol (9.6 mL, 100 mmol, 2.0 eq) and the mixture was slowly warmed to room temperature. After 20 hours, the reaction was concentrated under reduced pressure, dissolved into 350 mL EtOAc, washed with 400 mL sat. bicarbonate and 200 mL saturated aqueous NaCl. The organic was dried over MgSO4, filtered, and concentrated under reduced pressure to yield intermediate (19a) as a semisolid (7.3 g).

1. concentrationthe reaction was concentrated under reduced pressure
2. dissolutiondissolved into 350 mL EtOAc
3. washwashed with 400 mL sat. bicarbonate and 200 mL saturated aqueous NaCl
4. dry with materialThe organic was dried over MgSO4
5. filtrationfiltered
6. concentrationconcentrated under reduced pressure