HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 907252Generated: October 30, 2026
3-Hydroxybenzyl alcohol → {3-[3-(Dimethylamino)propoxy]phenyl}methanol
https://huagongshe.com/reaction/907252
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Hydroxybenzyl alcohol | HCID 102 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 3-(Dimethylamino)propyl chloride hydrochloride | HCID 94308 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | {3-[3-(Dimethylamino)propoxy]phenyl}methanol | HCID 24229604 | — |
Reaction Steps
Cesium carbonate (15.4 g) was added to a solution of 3-hydroxymethyl-phenol (3 g) in DMF (80 mL). To this mixture was added (3-chloro-propyl)-dimethyl-amine hydrochloride (4 g). The mixture was heated at 80° C. for 20 hours then allowed to cool. The reaction mixture was poured into water and extracted with ethyl acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08012979B2 |
|---|
| Source dataset | uspto-grants-2011_09 |
|---|
| ORD ID | ord-71e4c966cb49405586c71b9ed62f7d0b |
|---|
| Source note | uspto-grants-2011_09 |
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