HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → 6-Bromoisochroman-1,3-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | 4-Bromo-2-(carboxymethyl)benzoic acid | HCID 53440132 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 6-Bromoisochroman-1,3-dione | HCID 21782486 | — |
Reaction Steps
A solution of 4-bromo-2-carboxymethyl-benzoic acid (product of step i)) (11.0 g) in acetone (200 mL) was treated with acetyl chloride (13.3 g) and the solution stirred at room temperature for 17 hours. The reaction mixture was evaporated then azeotroped with toluene to yield the sub-title compound (9.8 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08012979B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-653cc442b39f4443afe07810e18e60a5 |
| Source note | uspto-grants-2011_09 |