HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → Methyl 4-((6-(5-(cyclopropylcarbamoyl)-2-methylphenyl)-1-oxoisoquinolin-2(1H)-yl)methyl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl 4-(bromomethyl)benzoate | HCID 256687 | — |
| Reactant | N-Cyclopropyl-4-methyl-3-(1-oxo-1,2-dihydro-isoquinolin-6-yl)-benzamide | HCID 25020457 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Methyl 4-((6-(5-(cyclopropylcarbamoyl)-2-methylphenyl)-1-oxoisoquinolin-2(1H)-yl)methyl)benzoate | HCID 57551782 | — |
Reaction Steps
A mixture of N-cyclopropyl-4-methyl-3-(1-oxo-1,2-dihydroisoquinolin-6-yl)benzamide (Example 11) (1.0 g), potassium carbonate (1.3 g) and methyl 4-(bromomethyl)benzoate (0.86 g) in DMF (10 mL) was stirred at room temperature for 17 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08012979B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-8d859b3cbad643e18505ff30fb061126 |
| Source note | uspto-grants-2011_09 |