HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 3-(2-((6-Bromopyridin-3-yl)methyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-N-cyclopropyl-4-methylbenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-Bromo-5-bromomethylpyridine | HCID 6424660 | — |
| Reactant | N-Cyclopropyl-4-methyl-3-(1-oxo-1,2-dihydro-isoquinolin-6-yl)-benzamide | HCID 25020457 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-(2-((6-Bromopyridin-3-yl)methyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-N-cyclopropyl-4-methylbenzamide | HCID 57551791 | — |
Reaction Steps
To a solution of the product of Example 11 (400 mg) in DMF (5 mL) was added sodium hydride (60 mg) and the reaction stirred at room temperature for 10 minutes before the addition of a solution of 2-bromo-5-(bromomethyl)pyridine (760 mg) in DMF (5 mL). The reaction mixture was stirred at room temperature for 30 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08012979B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-b846acf16a9648ed95c514834a761eb2 |
| Source note | uspto-grants-2011_09 |