反应详情

To a solution of the product of step iv) (1.5 g) in methanol (20 mL) at reflux was added sodium hydroxide (1N, 5.23 mL) and the solution stirred at this temperature for 30 min. The reaction mixture was treated with acetic acid (0.34 mL) and water and stirred overnight at room temperature. The solid was filtered and washed with methanol:water (1:1) then water. The solid was dried under vacuum at 60° C. to yield the sub-title compound (1.25 g).

1. stirringstirred overnight at room temperature
2. filtrationThe solid was filtered
3. washwashed with methanol:water (1:1)
4. customThe solid was dried under vacuum at 60° C.