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Diisopropylethylamine → HCID 25020019、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | (3R)-pyrrolidin-3-amine | HCID 1519352 | — |
| 反応物 | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| 反応物 | HCID 57551760 | HCID 57551760 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | HCID 25020019 | HCID 25020019 | — |
反応手順
To a solution of the product of step v) (100 mg), (R)-pyrrolidin-3-amine (20 mg) and N,N-diisopropylethylamine (0.13 mL) in DMF (2 mL) was added HATU (140 mg) and the reaction stirred at room temperature for 10 minutes. The reaction mixture was filtered and purified by HPLC to yield the title compound as a solid (65 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08012979B2 |
| 出典データセット | uspto-grants-2011_09 |
| ORD ID | ord-87f04dd011a9481f9fca6a3d1746adea |
| 出典メモ | uspto-grants-2011_09 |