反应详情

温度

50 °C

A mixture of the product of step ii) (0.88 g) and 5N sodium hydroxide (2.3 mL) in methanol (20 mL) was heated at 50° C. for 2 hours and then allowed to cool to room temperature. The reaction mixture was treated with glacial acetic acid (1 mL) and then water (20 mL). The precipitate was collected by filtration, washed with water and dried under vacuum to afford the sub-title compound (0.77 g).

1. temperatureto cool to room temperature
2. filtrationThe precipitate was collected by filtration
3. washwashed with water
4. customdried under vacuum