反应详情

温度

50 °C

To a mixture of the product of step ii) (0.7 g) in methanol (15 mL) was added a 5M aqueous solution of sodium hydroxide (1.8 mL) and the reaction heated at 50° C. for 6 hours. The reaction mixture was allowed to cool to room temperature and then treated with water (20 mL). The precipitate was collected by filtration, washed with water and dried to give the sub-title compound (0.52 g).

1. temperatureto cool to room temperature
2. filtrationThe precipitate was collected by filtration
3. washwashed with water
4. customdried