Water → HCID 57551817, compound

Participants

Reaction Steps

The product of Example 59 step iii) (0.25 g), (S)-2-methylpiperazine-1-carboxylic acid, tert-butyl ester (0.37 g) and sodium triacetoxyborohydride (0.40 g) were stirred in dichloromethane (20 mL) under nitrogen for 16 hours. Water (20 mL) and dichloromethane (20 mL) were then added and the organics separated. The organics were evaporated under reduced pressure. The residue was dissolved in methanol (5 mL) and 4M HCl in 1,4-dioxane (2 mL) added. The mixture was stirred overnight at room temperature. The volatiles were removed under vacuum and the residue purified by HPLC to give the title compound as a solid (0.11 g).

Provenance & Evidence