HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylpiperazine → N-Cyclopropyl-3-(2-(cyclopropylmethyl)-4-((4-methylpiperazin-1-yl)methyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-5-fluoro-4-methylbenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | N-Cyclopropyl-3-(2-(cyclopropylmethyl)-4-formyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-5-fluoro-4-methylbenzamide | HCID 57551841 | — |
| Product | N-Cyclopropyl-3-(2-(cyclopropylmethyl)-4-((4-methylpiperazin-1-yl)methyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-5-fluoro-4-methylbenzamide | HCID 57551795 | — |
Reaction Steps
The title compound was prepared as a solid according to the method of Example 75 step ii) using the product of Example 75 step i) and 1-methyl-piperazine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08012979B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-844534bcdb094073b152331a96bd3977 |
| Source note | uspto-grants-2011_09 |