tert-Butyl (2S)-2-methylpiperazine-1-carboxylate → HCID 57551828, compound

HRID 907312Notes

Reaction equation

HRID 907312 reaction equation
[CH:1]1([NH:4][C:5](=[O:31])[C:6]2[CH:11]=[C:10]([F:12])[C:9]([CH3:13])=[C:8]([C:14]3[CH:15]=[C:16]4[C:21](=[CH:22][CH:23]=3)[C:20](=[O:24])[N:19]([CH2:25][CH:26]3[CH2:28][CH2:27]3)[CH:18]=[C:17]4[CH:29]=O)[CH:7]=2)[CH2:3][CH2:2]1.[CH3:32][C@H:33]1[CH2:38][NH:37][CH2:36][CH2:35][N:34]1C(OC(C)(C)C)=O>>[CH:1]1([NH:4][C:5](=[O:31])[C:6]2[CH:11]=[C:10]([F:12])[C:9]([CH3:13])=[C:8]([C:14]3[CH:15]=[C:16]4[C:21](=[CH:22][CH:23]=3)[C:20](=[O:24])[N:19]([CH2:25][CH:26]3[CH2:27][CH2:28]3)[CH:18]=[C:17]4[CH2:29][N:37]3[CH2:36][CH2:35][NH:34][C@@H:33]([CH3:32])[CH2:38]3)[CH:7]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 10081508tert-Butyl (2S)-2-methylpiperazine-1-carboxylateHCID 57551841N-Cyclopropyl-3-(2-(cyclopropylmethyl)-4-formyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-5-fluoro-4-methylbenzamide

Product 1

HCID 57551828HCID 57551828, compound

Procedure

The title compound was prepared as a solid according to the method of Example 81 using the product of Example 75 step i) and (S)-2-methylpiperazine-1-carboxylic acid, tert-butyl ester and purified by HPLC.

Workup

  1. custompurified by HPLC

Sources & evidence

ORD record
ord-b8684070f7954c24b728ae93142b457b
Source dataset
uspto-grants-2011_09
Patent number
US08012979B2

Reaction notes

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