(R)-1-Boc-3-methylpiperazine → HCID 57551767, compound

HRID 907315Notes

Reaction equation

HRID 907315 reaction equation
[CH:1]1([NH:4][C:5](=[O:31])[C:6]2[CH:11]=[C:10]([F:12])[C:9]([CH3:13])=[C:8]([C:14]3[CH:15]=[C:16]4[C:21](=[CH:22][CH:23]=3)[C:20](=[O:24])[N:19]([CH2:25][CH:26]3[CH2:28][CH2:27]3)[CH:18]=[C:17]4[CH:29]=O)[CH:7]=2)[CH2:3][CH2:2]1.[CH3:32][C@H:33]1[NH:38][CH2:37][CH2:36][N:35](C(OC(C)(C)C)=O)[CH2:34]1>>[CH:1]1([NH:4][C:5](=[O:31])[C:6]2[CH:11]=[C:10]([F:12])[C:9]([CH3:13])=[C:8]([C:14]3[CH:15]=[C:16]4[C:21](=[CH:22][CH:23]=3)[C:20](=[O:24])[N:19]([CH2:25][CH:26]3[CH2:28][CH2:27]3)[CH:18]=[C:17]4[CH2:29][N:38]3[CH2:37][CH2:36][NH:35][CH2:34][C@H:33]3[CH3:32])[CH:7]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 2756811(R)-1-Boc-3-methylpiperazineHCID 57551841N-Cyclopropyl-3-(2-(cyclopropylmethyl)-4-formyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-5-fluoro-4-methylbenzamide

Product 1

HCID 57551767HCID 57551767, compound

Procedure

The title compound was prepared as a solid according to the method of Example 81 using the product of Example 75 step i) and (R)-3-methylpiperazine-1-carboxylic acid, tert-butyl ester and the product purified by HPLC.

Workup

  1. customthe product purified by HPLC

Sources & evidence

ORD record
ord-bc50a7070ed1449a87340fe544af49ea
Source dataset
uspto-grants-2011_09
Patent number
US08012979B2

Reaction notes

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