1-Boc-4-(aminomethyl)piperidine → HCID 57551717, compound

HRID 907318Notes

Reaction equation

HRID 907318 reaction equation
[CH:1]1([NH:4][C:5](=[O:31])[C:6]2[CH:11]=[C:10]([F:12])[C:9]([CH3:13])=[C:8]([C:14]3[CH:15]=[C:16]4[C:21](=[CH:22][CH:23]=3)[C:20](=[O:24])[N:19]([CH2:25][CH:26]3[CH2:28][CH2:27]3)[CH:18]=[C:17]4[CH:29]=O)[CH:7]=2)[CH2:3][CH2:2]1.C(OC([N:39]1[CH2:44][CH2:43][CH:42]([CH2:45][NH2:46])[CH2:41][CH2:40]1)=O)(C)(C)C>>[CH:1]1([NH:4][C:5](=[O:31])[C:6]2[CH:11]=[C:10]([F:12])[C:9]([CH3:13])=[C:8]([C:14]3[CH:15]=[C:16]4[C:21](=[CH:22][CH:23]=3)[C:20](=[O:24])[N:19]([CH2:25][CH:26]3[CH2:27][CH2:28]3)[CH:18]=[C:17]4[CH2:29][NH:46][CH2:45][CH:42]3[CH2:43][CH2:44][NH:39][CH2:40][CH2:41]3)[CH:7]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 7368171-Boc-4-(aminomethyl)piperidineHCID 57551841N-Cyclopropyl-3-(2-(cyclopropylmethyl)-4-formyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-5-fluoro-4-methylbenzamide

Product 1

HCID 57551717HCID 57551717, compound

Procedure

The title compound was prepared as a solid according to the method of Example 81 using the product of Example 75 step i) and 4-aminomethyl-piperidine-1-carboxylic acid tert-butyl ester.

Sources & evidence

ORD record
ord-8b3b5d92e64f4be99bd68d61b6530ab9
Source dataset
uspto-grants-2011_09
Patent number
US08012979B2

Reaction notes

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