1-(2-Hydroxyethyl)piperazine → N-Cyclopropyl-3-(2-(cyclopropylmethyl)-4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-5-fluoro-4-methylbenzamide

HRID 907319Notes

Reaction equation

HRID 907319 reaction equation
[CH:1]1([NH:4][C:5](=[O:31])[C:6]2[CH:11]=[C:10]([F:12])[C:9]([CH3:13])=[C:8]([C:14]3[CH:15]=[C:16]4[C:21](=[CH:22][CH:23]=3)[C:20](=[O:24])[N:19]([CH2:25][CH:26]3[CH2:28][CH2:27]3)[CH:18]=[C:17]4[CH:29]=O)[CH:7]=2)[CH2:3][CH2:2]1.[N:32]1([CH2:38][CH2:39][OH:40])[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1>>[CH:1]1([NH:4][C:5](=[O:31])[C:6]2[CH:11]=[C:10]([F:12])[C:9]([CH3:13])=[C:8]([C:14]3[CH:15]=[C:16]4[C:21](=[CH:22][CH:23]=3)[C:20](=[O:24])[N:19]([CH2:25][CH:26]3[CH2:27][CH2:28]3)[CH:18]=[C:17]4[CH2:29][N:35]3[CH2:36][CH2:37][N:32]([CH2:38][CH2:39][OH:40])[CH2:33][CH2:34]3)[CH:7]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 57551841N-Cyclopropyl-3-(2-(cyclopropylmethyl)-4-formyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-5-fluoro-4-methylbenzamide

Product 1

HCID 25020346N-Cyclopropyl-3-(2-(cyclopropylmethyl)-4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-5-fluoro-4-methylbenzamide

Procedure

The title compound was prepared as a solid according to the method of Example 75 step ii) using product of Example 75 step i) and 2-piperazin-1-yl-ethanol.

Sources & evidence

ORD record
ord-4f29d79be2f9496c84f328a3573f1e10
Source dataset
uspto-grants-2011_09
Patent number
US08012979B2

Reaction notes

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