(1-Ethylpiperidin-4-yl)methanamine → N-Cyclopropyl-3-(2-(cyclopropylmethyl)-4-(((1-ethylpiperidin-4-yl)methylamino)methyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-5-fluoro-4-methylbenzamide

HRID 907320Notes

Reaction equation

HRID 907320 reaction equation
[CH:1]1([NH:4][C:5](=[O:31])[C:6]2[CH:11]=[C:10]([F:12])[C:9]([CH3:13])=[C:8]([C:14]3[CH:15]=[C:16]4[C:21](=[CH:22][CH:23]=3)[C:20](=[O:24])[N:19]([CH2:25][CH:26]3[CH2:28][CH2:27]3)[CH:18]=[C:17]4[CH:29]=O)[CH:7]=2)[CH2:3][CH2:2]1.[CH2:32]([N:34]1[CH2:39][CH2:38][CH:37]([CH2:40][NH2:41])[CH2:36][CH2:35]1)[CH3:33]>>[CH:1]1([NH:4][C:5](=[O:31])[C:6]2[CH:11]=[C:10]([F:12])[C:9]([CH3:13])=[C:8]([C:14]3[CH:15]=[C:16]4[C:21](=[CH:22][CH:23]=3)[C:20](=[O:24])[N:19]([CH2:25][CH:26]3[CH2:27][CH2:28]3)[CH:18]=[C:17]4[CH2:29][NH:41][CH2:40][CH:37]3[CH2:38][CH2:39][N:34]([CH2:32][CH3:33])[CH2:35][CH2:36]3)[CH:7]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 2794704(1-Ethylpiperidin-4-yl)methanamineHCID 57551841N-Cyclopropyl-3-(2-(cyclopropylmethyl)-4-formyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-5-fluoro-4-methylbenzamide

Product 1

HCID 57551749N-Cyclopropyl-3-(2-(cyclopropylmethyl)-4-(((1-ethylpiperidin-4-yl)methylamino)methyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-5-fluoro-4-methylbenzamide

Procedure

The title compound was prepared as a solid according to the method of Example 75 step ii) using product of Example 75 step i) and C-(1-ethyl-piperidin-4-yl)-methylamine.

Sources & evidence

ORD record
ord-31061c5bc00947448d0c9c9ca0066e91
Source dataset
uspto-grants-2011_09
Patent number
US08012979B2

Reaction notes

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