4-Methyl-3-(1-oxo-1,2-dihydro-isoquinolin-6-yl)-benzoic acid, methyl ester → 4-Methyl-3-(3-methyl-1-oxo-1,2-dihydro-isoquinolin-4-yl)-benzoic acid, methyl ester

HRID 907323Notes

Reaction equation

HRID 907323 reaction equation
[CH3:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=1C1C=C2C(=CC=1)C(=O)NC=C2.Br[C:24]1[CH:25]=[C:26]2[C:31](=[CH:32][CH:33]=1)[C:30](=[O:34])[NH:29][C:28]([CH3:35])=[CH:27]2>>[CH3:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=1[C:27]1[C:26]2[C:31](=[CH:32][CH:33]=[CH:24][CH:25]=2)[C:30](=[O:34])[NH:29][C:28]=1[CH3:35]

Participants

3

Reactant 2

HCID 575518084-Methyl-3-(1-oxo-1,2-dihydro-isoquinolin-6-yl)-benzoic acid, methyl esterHCID 575518146-Bromo-3-methyl-1,2-dihydroisoquinolin-1-one

Product 1

HCID 866264534-Methyl-3-(3-methyl-1-oxo-1,2-dihydro-isoquinolin-4-yl)-benzoic acid, methyl ester

Procedure

The sub-title compound was prepared by the method of intermediate 3 using the product of step i).

Sources & evidence

ORD record
ord-5d949de0231a424aad7dce2fb31b81bf
Source dataset
uspto-grants-2011_09
Patent number
US08012979B2

Reaction notes

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