N-Cyclopropyl-3-(2-(cyclopropylmethyl)-4-formyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-5-fluoro-4-methylbenzamide → HCID 25020402, compound

HRID 907336Notes

Reaction equation

HRID 907336 reaction equation
[CH:1]1([NH:4][C:5](=[O:31])[C:6]2[CH:11]=[C:10]([F:12])[C:9]([CH3:13])=[C:8]([C:14]3[CH:15]=[C:16]4[C:21](=[CH:22][CH:23]=3)[C:20](=[O:24])[N:19]([CH2:25][CH:26]3[CH2:28][CH2:27]3)[CH:18]=[C:17]4[CH:29]=O)[CH:7]=2)[CH2:3][CH2:2]1.[CH3:32][C@@H:33]1[CH2:38][NH:37][CH2:36][CH2:35][N:34]1C(O)=O>>[CH:1]1([NH:4][C:5](=[O:31])[C:6]2[CH:11]=[C:10]([F:12])[C:9]([CH3:13])=[C:8]([C:14]3[CH:15]=[C:16]4[C:21](=[CH:22][CH:23]=3)[C:20](=[O:24])[N:19]([CH2:25][CH:26]3[CH2:27][CH2:28]3)[CH:18]=[C:17]4[CH2:29][N:37]3[CH2:36][CH2:35][NH:34][C@H:33]([CH3:32])[CH2:38]3)[CH:7]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 57551841N-Cyclopropyl-3-(2-(cyclopropylmethyl)-4-formyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-5-fluoro-4-methylbenzamideHCID 67399488HCID 67399488, compound

Product 1

HCID 25020402HCID 25020402, compound

Procedure

The title compound was prepared as a solid according to the method of Example 81 using the product of Example 75 step i) and (R)-2-methyl-piperazine-1-carboxylic acid tert, butyl ester and the product purified by SiO2 chromatography (eluting with 93:5:2 dichloromethane:methanol:ammonia).

Workup

  1. customthe product purified by SiO2 chromatography (eluting with 93:5:2 dichloromethane:methanol:ammonia)

Sources & evidence

ORD record
ord-36344a0b91784bdba15e98d59e6e72c1
Source dataset
uspto-grants-2011_09
Patent number
US08012979B2

Reaction notes

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