HRID907342

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID24820219

tert-Butyl (2R)-2-(hydroxymethyl)piperazine-1-carboxylate

C10H20N2O3

结构：Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc2c(=O)n(Cc3ccc(S(C)(=O)=O)cc3)cc(C=O)c2c1

HCID57551746

未命名化合物

PRODUCTS

生成物

结构：Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc2c(=O)n(Cc3ccc(S(C)(=O)=O)cc3)cc(CN3CCN[C@@H](CO)C3)c2c1

HCID57551788

未命名化合物

PROCEDURE

实验过程

The title compound was prepared as a solid according to the method of Example 81 using the product of Example 112 step i) and (R)-2-(hydroxymethyl)-piperazine-1-carboxylic acid, tert-butyl ester.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a5307d702c5440cd8551f49b1c9b6167
来源数据集: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08012979B2
来源说明: uspto-grants-2011_09

反应 SMILES

[CH:1]1([NH:4][C:5](=[O:38])[C:6]2[CH:11]=[C:10]([C:12]3[CH:13]=[C:14]4[C:19](=[CH:20][CH:21]=3)[C:18](=[O:22])[N:17]([CH2:23][C:24]3[CH:29]=[CH:28][C:27]([S:30]([CH3:33])(=[O:32])=[O:31])=[CH:26][CH:25]=3)[CH:16]=[C:15]4[CH:34]=O)[C:9]([CH3:36])=[C:8]([F:37])[CH:7]=2)[CH2:3][CH2:2]1.[OH:39][CH2:40][C@H:41]1[CH2:46][NH:45][CH2:44][CH2:43][N:42]1C(OC(C)(C)C)=O>>[CH:1]1([NH:4][C:5](=[O:38])[C:6]2[CH:11]=[C:10]([C:12]3[CH:13]=[C:14]4[C:19](=[CH:20][CH:21]=3)[C:18](=[O:22])[N:17]([CH2:23][C:24]3[CH:29]=[CH:28][C:27]([S:30]([CH3:33])(=[O:31])=[O:32])=[CH:26][CH:25]=3)[CH:16]=[C:15]4[CH2:34][N:45]3[CH2:44][CH2:43][NH:42][C@@H:41]([CH2:40][OH:39])[CH2:46]3)[C:9]([CH3:36])=[C:8]([F:37])[CH:7]=2)[CH2:3][CH2:2]1