(S)-tert-butyl 2-(2-hydroxyethyl)piperazine-1-carboxylate → (S)-N-Cyclopropyl-3-(2-(cyclopropylmethyl)-4-((3-(2-hydroxyethyl)piperazin-1-yl)methyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-5-fluoro-4-methylbenzamide

HRID 907344Notes

Reaction equation

HRID 907344 reaction equation
[CH:1]1([NH:4][C:5](=[O:31])[C:6]2[CH:11]=[C:10]([F:12])[C:9]([CH3:13])=[C:8]([C:14]3[CH:15]=[C:16]4[C:21](=[CH:22][CH:23]=3)[C:20](=[O:24])[N:19]([CH2:25][CH:26]3[CH2:28][CH2:27]3)[CH:18]=[C:17]4[CH:29]=O)[CH:7]=2)[CH2:3][CH2:2]1.[OH:32][CH2:33][CH2:34][C@H:35]1[CH2:40][NH:39][CH2:38][CH2:37][N:36]1C(OC(C)(C)C)=O>>[CH:1]1([NH:4][C:5](=[O:31])[C:6]2[CH:11]=[C:10]([F:12])[C:9]([CH3:13])=[C:8]([C:14]3[CH:15]=[C:16]4[C:21](=[CH:22][CH:23]=3)[C:20](=[O:24])[N:19]([CH2:25][CH:26]3[CH2:27][CH2:28]3)[CH:18]=[C:17]4[CH2:29][N:39]3[CH2:38][CH2:37][NH:36][C@@H:35]([CH2:34][CH2:33][OH:32])[CH2:40]3)[CH:7]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 12046236(S)-tert-butyl 2-(2-hydroxyethyl)piperazine-1-carboxylateHCID 57551841N-Cyclopropyl-3-(2-(cyclopropylmethyl)-4-formyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-5-fluoro-4-methylbenzamide

Product 1

HCID 25020403(S)-N-Cyclopropyl-3-(2-(cyclopropylmethyl)-4-((3-(2-hydroxyethyl)piperazin-1-yl)methyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-5-fluoro-4-methylbenzamide

Procedure

The title compound was prepared as a solid according to the method of Example 81 using the product of Example 75 step i) and (S)-2-(hydroxy-ethyl)-piperazine-1-carboxylic acid, tert-butyl ester.

Sources & evidence

ORD record
ord-4ae29e4b984141f294097e0071086b3c
Source dataset
uspto-grants-2011_09
Patent number
US08012979B2

Reaction notes

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