HCID 45072436, compound → HCID 57551723, compound

HRID 907346Notes

Reaction equation

HRID 907346 reaction equation
[CH:1]1([NH:4][C:5](=[O:31])[C:6]2[CH:11]=[C:10]([F:12])[C:9]([CH3:13])=[C:8]([C:14]3[CH:15]=[C:16]4[C:21](=[CH:22][CH:23]=3)[C:20](=[O:24])[N:19]([CH2:25][CH:26]3[CH2:28][CH2:27]3)[CH:18]=[C:17]4[CH:29]=O)[CH:7]=2)[CH2:3][CH2:2]1.[OH:32][CH2:33][C@@H:34]1[NH:38][CH2:37][C@@H:36]([NH:39]C(=O)OC(C)(C)C)[CH2:35]1>>[NH2:39][C@@H:36]1[CH2:37][N:38]([CH2:29][C:17]2[C:16]3[C:21](=[CH:22][CH:23]=[C:14]([C:8]4[CH:7]=[C:6]([CH:11]=[C:10]([F:12])[C:9]=4[CH3:13])[C:5]([NH:4][CH:1]4[CH2:3][CH2:2]4)=[O:31])[CH:15]=3)[C:20](=[O:24])[N:19]([CH2:25][CH:26]3[CH2:27][CH2:28]3)[CH:18]=2)[C@@H:34]([CH2:33][OH:32])[CH2:35]1

Participants

3

Reactant 2

HCID 45072436HCID 45072436, compoundHCID 57551841N-Cyclopropyl-3-(2-(cyclopropylmethyl)-4-formyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-5-fluoro-4-methylbenzamide

Product 1

HCID 57551723HCID 57551723, compound

Procedure

The title compound was prepared as a solid according to the method of Example 81 using the product of Example 75 step i) and ((3S,5R)-5-hydroxymethyl-pyrrolidin-3-yl)-carbamic acid, tert-butyl ester.

Sources & evidence

ORD record
ord-3eb924912a0a41069f77446dcf2df233
Source dataset
uspto-grants-2011_09
Patent number
US08012979B2

Reaction notes

Loading…