HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl {[(2R)-pyrrolidin-2-yl]methyl}carbamate--hydrogen chloride (1/1) → HCID 57551839, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl {[(2R)-pyrrolidin-2-yl]methyl}carbamate--hydrogen chloride (1/1) | HCID 45072307 | — |
| Reactant | N-Cyclopropyl-3-(2-(cyclopropylmethyl)-4-formyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-5-fluoro-4-methylbenzamide | HCID 57551841 | — |
| Product | HCID 57551839 | HCID 57551839 | — |
Reaction Steps
The title compound was prepared as a solid according to the method of Example 81 using the product of Example 75 step i) and (R)-1-pyrrolidine-2-ylmethyl-carbamic acid tert-butyl ester hydrochloride. The product was purified using SCX ion-exchange chromatography (eluting with methanol followed by 3N ammonia in methanol), followed by HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08012979B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-59aa7c64fd5b45f894f1c5242f2f3663 |
| Source note | uspto-grants-2011_09 |