HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 907349Generated: October 30, 2026
Potassium Carbonate → HCID 57551784, compound
https://huagongshe.com/reaction/907349
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Bromomethylcyclopropane | HCID 81503 | — |
| Reactant | N-Cyclopropyl-4-methyl-3-(1-oxo-1,2-dihydro-isoquinolin-6-yl)-benzamide | HCID 25020457 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 57551784 | HCID 57551784 | 59.8% |
Reaction Steps
A mixture of the product of Example 11 (100 mg), potassium carbonate (174 mg) and (bromomethyl)cyclopropane (63 mg) in DMF (2 mL) was stirred at room temperature for 16 hours and at 70° C. for 24 hours. Further (bromomethyl)cyclopropane (300 mg) was added and the mixture heated at 70° C. for a further 24 hours. The reaction mixture was filtered and purified by HPLC to give the title compound (70 mg) as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08012979B2 |
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| Source dataset | uspto-grants-2011_09 |
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| ORD ID | ord-ad8bdc2592034656ac10ab9efb8e255f |
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| Source note | uspto-grants-2011_09 |
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