tert-Butyl {[(2S)-pyrrolidin-2-yl]methyl}carbamate--hydrogen chloride (1/1) → HCID 57551800, compound

HRID 907356Notes

Reaction equation

HRID 907356 reaction equation
[CH:1]1([NH:4][C:5](=[O:31])[C:6]2[CH:11]=[C:10]([F:12])[C:9]([CH3:13])=[C:8]([C:14]3[CH:15]=[C:16]4[C:21](=[CH:22][CH:23]=3)[C:20](=[O:24])[N:19]([CH2:25][CH:26]3[CH2:28][CH2:27]3)[CH:18]=[C:17]4[CH:29]=O)[CH:7]=2)[CH2:3][CH2:2]1.Cl.C(OC(=O)[NH:39][CH2:40][C@@H:41]1[CH2:45][CH2:44][CH2:43][NH:42]1)(C)(C)C>>[NH2:39][CH2:40][C@@H:41]1[CH2:45][CH2:44][CH2:43][N:42]1[CH2:29][C:17]1[C:16]2[C:21](=[CH:22][CH:23]=[C:14]([C:8]3[CH:7]=[C:6]([CH:11]=[C:10]([F:12])[C:9]=3[CH3:13])[C:5]([NH:4][CH:1]3[CH2:2][CH2:3]3)=[O:31])[CH:15]=2)[C:20](=[O:24])[N:19]([CH2:25][CH:26]2[CH2:28][CH2:27]2)[CH:18]=1

Participants

3

Reactant 2

HCID 44828652tert-Butyl {[(2S)-pyrrolidin-2-yl]methyl}carbamate--hydrogen chloride (1/1)HCID 57551841N-Cyclopropyl-3-(2-(cyclopropylmethyl)-4-formyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-5-fluoro-4-methylbenzamide

Product 1

HCID 57551800HCID 57551800, compound

Procedure

The title compound was prepared according to the method of Example 81 using the product of Example 75 step i) and (S)-1-pyrrolidine-2-ylmethyl-carbamic acid tert-butyl ester hydrochloride. The product was purified using SCX ion-exchange chromatography (eluting with methanol followed by 3N ammonia in methanol), followed by HPLC.

Workup

  1. customThe product was purified
  2. washSCX ion-exchange chromatography (eluting with methanol followed by 3N ammonia in methanol)

Sources & evidence

ORD record
ord-c715d5c77cc74fd4a8233a26ef1d5fe7
Source dataset
uspto-grants-2011_09
Patent number
US08012979B2

Reaction notes

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