Lithium Hydroxide → HCID 86638099, compound

Participants

Reaction Steps

Methyl 5-isopentyl-2-{[(1-methyl-4-nitro-1H-pyrrol-2-yl)carbonyl]amino}-1,3-thiazole-4-carboxylate (660 mg, 1.74 mmol; see step (iii) above) was suspended in a mixture of water (25 mL) and methanol (5 mL) containing lithium hydroxide (125 mg, 5.21 mmol). The reaction mixture was stirred vigorously for 48 h at room temperature. Some of the methanol was removed under partial reduced pressure at 50° C. The cooled solution was extracted with ether and the ethereal layer was discarded. The aqueous layer was cooled to 0° C. and acidified by adding HCl (Concentrated) dropwise with stirring. The pale yellow solid was filtered off, washed with water and dried overnight at 45° C. under reduced pressure to give the sub-title compound (584 mg, 92% yield), m.p.=296-300° C.

Provenance & Evidence