N,N-Dimethyl-1,3-propanediamine → HCID 86638101, compound

Participants

Reaction Steps

5-Isopentyl-2-{[(1-methyl-4-nitro-1H-pyrrol-2-yl)carbonyl]amino}-1,3-thiazole-4-carboxylic acid (570 mg, 1.56 mmol; see step (iv) above) was dissolved in DMF (2.5 mL, dry) to which NMM (0.5 mL, dry), HBTU (1.18 g, 3.12 mmol) and dimethylaminopropylamine (318 mg, 3.12 mmol, Aldrich) were added at room temperature with stirring. After the standard work up and purification, the sub-title compound was obtained as a yellow solid (660 mg, 94%), m.p.>230° C.

Provenance & Evidence