HCID 86638101, compound → HCID 23730505, compound

Participants

Reaction Steps

N-[3-(Dimethylamino)propyl]-5-isopentyl-2-{[(1-methyl-4-nitro-1H-pyrrol-2-yl)carbonyl]amino}-1,3-thiazole-4-carboxamide (265 mg, 0.588 mmol; see step (v) above) was suspended in methanol (25 mL) to which Pd/C-10% (300 mg) was added at 0° C. under a nitrogen with stirring. The reaction mixture was hydrogenated for 3 h at room temperature and atmospheric pressure. The catalyst was removed over Kieselguhr and methanol was removed under reduced pressure to give the title compound, which was used without further purification.

Provenance & Evidence