Water → HCID 67392410, compound

Participants

Reaction Steps

Ethyl-1-methyl-4-[(E)-2-(4-nitrophenyl)ethenyl]-1H-pyrrole-2-carboxylate (0.100 mg, 0.333 mmol; see step (ii) above) was suspended in ethanol (4 mL), THF (8 mL) and water (20 mL) to which sodium hydroxide solution (NaOH 0.190 g, 4.75 mmol in water 10 mL) was added with stirring. The reaction mixture was heated under reflux for 4 h. The reaction mixture was cooled to room temperature then HCl(conc.) was added dropwise with vigorous stirring until pH 2 was attained. The yellow, solid material was filtered off, washed with water and dried in vacuo at 60° C. to provide the title compound (50 mg, 55%), m.p.=212-215° C. (decomposition).

Provenance & Evidence