反应详情

2,2-Diethoxyethanethioamide (0.654 g, 6.03 mmol; see step (iii) above) and ethylbromopyruvate (Aldrich) (1.28 g, 6.10 mmol) were dissolved in ethanol (10 mL) in the presence of 4 Å molecular sieves (1 g). The mixture was refluxed for 45 min and the solvent removed under reduced pressure. The residue was then dissolved in ethyl acetate (20 mL) and extracted with saturated. NaHCO3 solution (2×20 mL), and brine (2×20 mL). The organic fraction was then dried (MgSO4), filtered and the solvent removed under reduced pressure to yield the sub-title compound (1.452 g, 93%).

1. temperatureThe mixture was refluxed for 45 min
2. customthe solvent removed under reduced pressure
3. dissolutionThe residue was then dissolved in ethyl acetate (20 mL)
4. extractionextracted with saturated
5. dry with materialThe organic fraction was then dried (MgSO4)
6. filtrationfiltered
7. customthe solvent removed under reduced pressure