Sodium Hydroxide → HCID 67392233, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 6-{(E)-2-[4-(methylsulfanyl)phenyl]ethenyl}nicotinate (80 mg, 0.280 mmol; see step (i) above) was suspended in methanol (4 mL) and a solution of sodium hydroxide (250 mg, in water 10 mL) and the reaction mixture was heated under reflux for 4 h. The solvent was removed under reduced pressure and the aqueous layer was extracted with DCM. The aqueous layer was cooled to 0° C. with ice then HCl(conc.) was added dropwise with stirring until pH4, where a precipitate formed. The solid material was filtered, washed with water and dried under reduced pressure to give the title compound as pale yellow solid (75 mg, 99%).

Provenance & Evidence