Methanol → HCID 22722084, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 6-[(E)-2-(4-methoxyphenyl)ethenyl]nicotinate (80 mg, 0.297 mmol; see step (i) above) was dissolved in methanol (5 mL) to which sodium hydroxide solution (145 mg in 10 mL water) was added. The reaction mixture was heated under reflux for 3 h. The solvent was removed under partial reduced pressure and the remaining solution was cooled to 0° C. Hydrochloric acid (conc.) was added dropwise with vigorous stirring until pH4 where a precipitate formed. The yellow solid material was collected by filtration, washed with water and dried under reduced pressure at 50° C. to give the title compound (59 mg, 78%).

Provenance & Evidence