Sodium Hydroxide → HCID 57939223, compound

HRID 907401Notes

Reaction equation

HRID 907401 reaction equation
[OH-].[Na+].[CH2:3]([O:14][C:15]1[CH:24]=[CH:23][CH:22]=[CH:21][C:16]=1[C:17]([O:19]C)=[O:18])[CH2:4][CH2:5]/[CH:6]=[CH:7]\[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13]>CO>[CH2:3]([O:14][C:15]1[CH:24]=[CH:23][CH:22]=[CH:21][C:16]=1[C:17]([OH:19])=[O:18])[CH2:4][CH2:5]/[CH:6]=[CH:7]\[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 57939225HCID 57939225, compound

Product 1

HCID 57939223HCID 57939223, compoundYield 99.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

500 μL of 1 N sodium hydroxide solution (500 μmol) are added portionwise to 80 mg of 29 (263 μmol) in methanol (3 mL). The solution is refluxed for 24 hours. After evaporating off the solvent, the reaction medium is acidified with 0.5 N HCl and extracted with DCM. 76 mg of a yellow oil are obtained, i.e. a yield of 99%.

Workup

  1. temperatureThe solution is refluxed for 24 hours
  2. customAfter evaporating off the solvent
  3. extractionextracted with DCM

Sources & evidence

ORD record
ord-1c512fac51c54d4ba04cd263c01d8f46
Source dataset
uspto-grants-2011_09
Patent number
US08013132B2

Reaction notes

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