4-Amino-3-chlorophenol → 4-amino-6-(4-amino-3-chloro-phenoxy)-pyrimidine-5-carbaldehyde O-methyl-oxime

Participants

Reaction Steps

Using the procedure for Example 9, 4-amino-6-chloro-pyrimidine-5-carbaldehyde O-methyl-oxime Compound 9a (0.20 g) and 4-amino-3-chloro-phenol Compound 10a (0.19 g) were reacted to provide 4-amino-6-(4-amino-3-chloro-phenoxy)-pyrimidine-5-carbaldehyde O-methyl-oxime Compound 10b (0.20 g, 65%). 1H NMR (400 MHz, DMSO-d6) δ 8.55 (s, 1H), 8.15 (s, 1H), 8.05 (s, 1H), 7.60 (s, 1H), 7.15 (s, 1H), 6.90 (d, 1H), 6.80 (d, 1H), 5.32 (s, 2H), 3.98 (s, 3H). MS (ESI) m/z: 299 (M+H+).

Provenance & Evidence