HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluoroaniline → N-(3-fluorophenyl)-2-(4-methoxyphenyl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluoroaniline | HCID 9742 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Methyl 4-methoxyphenylacetate | HCID 90266 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | N-(3-fluorophenyl)-2-(4-methoxyphenyl)acetamide | HCID 765698 | — |
Reaction Steps
Using the procedure for Example 22, (4-methoxy-phenyl)-acetic acid methyl ester Compound 22a was reacted with 3-fluoro-phenylamine and sodium hydride in DMSO at room temperature to provide N-(3-fluoro-phenyl)-2-(4-methoxy-phenyl)-acetamide Compound 23a. Compound 23a was reacted with borotribromide in dichloromethane to yield N-(3-fluoro-phenyl)-2-(4-hydroxy-phenyl)-acetamide Compound 23b.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08013153B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-84b4df770f5e40fc9d42806e5fcdafab |
| Source note | uspto-grants-2011_09 |