5-Pyrimidinecarboxaldehyde, 4-amino-6-chloro- → HCID 86616106, compound

HRID 907441Notes

Reaction equation

HRID 907441 reaction equation
[NH2:1][C:2]1[C:7]([CH:8]=[O:9])=[C:6](Cl)[N:5]=[CH:4][N:3]=1.[NH2:11][C:12]1[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][C:13]=1[Cl:19]>>[NH2:1][C:2]1[C:7]([CH:8]=[O:9])=[C:6]([O:18][C:15]2[CH:16]=[CH:17][C:12]([NH2:11])=[C:13]([Cl:19])[CH:14]=2)[N:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 842305-Pyrimidinecarboxaldehyde, 4-amino-6-chloro-HCID 871844-Amino-3-chlorophenol

Product 1

HCID 86616106HCID 86616106, compound

Procedure

Using the procedure for Example 1, 4-amino-6-chloro-pyrimidine-5-carbaldehyde Compound 1a was reacted with 4-amino-3-chloro-phenol Compound 10a to provide 4-amino-6-(4-amino-3-chloro-phenoxy)-pyrimidine-5-carbaldehyde Compound 26a.

Sources & evidence

ORD record
ord-6bfabe6a9ecf4df8a9c63b3eb2a4dd82
Source dataset
uspto-grants-2011_09
Patent number
US08013153B2

Reaction notes

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