HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 178465179, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | N-Ethyl-L-prolinamide--hydrogen chloride (1/1) | HCID 22804123 | — |
| Reactant | HCID 178491780 | HCID 178491780 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | HCID 178465179 | HCID 178465179 | 131.6% |
Reaction Steps
According to the general procedure for HBTU promoted coupling solutions of 31.5 g Boc-Arg(Mtr)-OH in DMAC, 24.79 g HBTU in DMAC, 11.56 g H-Pro-NHEt.HCl in DMAC and 19.60 g triethylamine in DMAC were premixed and fed into the reactor at 50° C. using a residence time of 1.1 min to yield 52 g crude material which was used in the next step without purification. The calculated yield from HPLC analysis was 99%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08013117B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-4761f4b5141b44c696910bb0443a7032 |
| Source note | uspto-grants-2011_09 |