Sodium Hydroxide → HCID 7039477, compound

HRID 907446Notes

Reaction equation

HRID 907446 reaction equation
[NH:1]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[C@@H:2]([C:7]([NH:9][C@H:10]([C:15]([O:17]CC=C)=[O:16])[CH2:11][CH:12]([CH3:14])[CH3:13])=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5].[OH-].[Na+]>C(O)C.O>[NH:1]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[C@@H:2]([C:7]([NH:9][C@H:10]([C:15]([OH:17])=[O:16])[CH2:11][CH:12]([CH3:14])[CH3:13])=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 131729165HCID 131729165, compound

Product 1

HCID 7039477HCID 7039477, compoundYield 91.4%

Reagents, catalysts & solvents 1

HCID 19096565Water ethanolSolvent

Procedure

According to the general saponification procedure, 6.11 g crude Boc-D-Leu-Leu-OAllyl were saponified with 3 g sodium hydroxide in ethanol/water to yield 5.0 g crude Boc-D-Leu-Leu-OH which was used in the next step without purification

Sources & evidence

ORD record
ord-d58d93f29cde4e8aa0ccd0b139c2ca14
Source dataset
uspto-grants-2011_09
Patent number
US08013117B2

Reaction notes

Loading…