HCID 178465177, compound → HCID 178465178, compound

HRID 907447Notes

Reaction equation

HRID 907447 reaction equation
[NH:1](C(OC(C)(C)C)=O)[C@@H:2]([C:7]([NH:9][C@H:10]([C:15]([NH:17][C@H:18]([C:40]([N:42]1[CH2:51][CH2:50][CH2:49][C@H:43]1[C:44]([NH:46][CH2:47][CH3:48])=[O:45])=[O:41])[CH2:19][CH2:20][CH2:21][NH:22][C:23](=[NH:39])[NH:24][S:25]([C:28]1[C:37]([CH3:38])=[C:35]([CH3:36])[C:32]([O:33][CH3:34])=[CH:31][C:29]=1[CH3:30])(=[O:27])=[O:26])=[O:16])[CH2:11][CH:12]([CH3:14])[CH3:13])=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5]>C(O)=O>[NH2:1][C@@H:2]([C:7]([NH:9][C@H:10]([C:15]([NH:17][C@H:18]([C:40]([N:42]1[CH2:51][CH2:50][CH2:49][C@H:43]1[C:44]([NH:46][CH2:47][CH3:48])=[O:45])=[O:41])[CH2:19][CH2:20][CH2:21][NH:22][C:23](=[NH:39])[NH:24][S:25]([C:28]1[C:37]([CH3:38])=[C:35]([CH3:36])[C:32]([O:33][CH3:34])=[CH:31][C:29]=1[CH3:30])(=[O:26])=[O:27])=[O:16])[CH2:11][CH:12]([CH3:14])[CH3:13])=[O:8])[CH2:3][CH:4]([CH3:5])[CH3:6]

Participants

3

Reactant 1

HCID 178465177HCID 178465177, compound

Product 1

HCID 178465178HCID 178465178, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

According to general procedure for BOC-cleavage, 500 mg crude Boc-D-Leu-Leu-Arg(Mtr)-Pro-NHEt was treated with 2 ml formic acid yielding 350 mg crude D-Leu-Leu-Arg (Mtr)-Pro-NHEt (yield based on HPLC: 80%).

Sources & evidence

ORD record
ord-0d3a404dd4b34548a3c48ef0951c65e9
Source dataset
uspto-grants-2011_09
Patent number
US08013117B2

Reaction notes

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