HuagongsheHuagongshe Chemistry Print Report · For research reference only
L-Pyroglutamic Acid → HCID 131729168, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | L-Pyroglutamic Acid | HCID 7405 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | Methyl 1-(triphenylmethyl)-L-histidinate--hydrogen chloride (1/1) | HCID 53229896 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 131729168 | HCID 131729168 | 99.3% |
Reaction Steps
According to the general procedure for HBTU promoted coupling, 4.7 g (10.5 mmol) H-His(Trt)-OMe.HCl, 4.54 g (10.8 mmol) HBTU, 2.69 g (10.5 mmol) Pyr-OH and 8.3 ml (26.3 mmol) DIPEA were reacted in a CYTOS® Lab System in anhydrous DMF at total flow of 26.7 ml/min and a residence time of 1.2 min to yield 5.3 g of crude Pyr-His(Trt)-OH which was used in the next step without purification. Yield based on HPLC: 81%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08013117B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-6bccb9e9fbed40029dfe614324bbd907 |
| Source note | uspto-grants-2011_09 |