Sodium Hydroxide → HCID 131729168, compound

HRID 907449Notes

Reaction equation

HRID 907449 reaction equation
[NH:1]1[C:5](=[O:6])[CH2:4][CH2:3][C@H:2]1[C:7]([NH:9][C@H:10]([C:36]([O:38]C)=[O:37])[CH2:11][C:12]1[N:16]=[CH:15][N:14]([C:17]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:13]=1)=[O:8].[OH-].[Na+]>C(O)C.O>[NH:1]1[C:5](=[O:6])[CH2:4][CH2:3][C@H:2]1[C:7]([NH:9][C@H:10]([C:36]([OH:38])=[O:37])[CH2:11][C:12]1[N:16]=[CH:15][N:14]([C:17]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:13]=1)=[O:8]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 91978696HCID 91978696, compound

Product 1

HCID 131729168HCID 131729168, compound

Reagents, catalysts & solvents 1

HCID 19096565Water ethanolSolvent

Procedure

According to the general procedure for saponification, 5.6 g crude Pyr-His(Trt)-OMe were treated with 3.6 g sodium hydroxide in ethanol/water yielding 5.6 g of crude material (yield based on HPLC: 99%)

Sources & evidence

ORD record
ord-1a8fb05985d34e5eb74abd0d59a2760d
Source dataset
uspto-grants-2011_09
Patent number
US08013117B2

Reaction notes

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