HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 131729169, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | N-(9-Fluorenylmethoxycarbonyl)-O-tert-butylserine | HCID 2724633 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | HCID 7021133 | HCID 7021133 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 131729169 | HCID 131729169 | 96% |
Reaction Steps
According to the general procedure for HBTU promoted coupling, 18.26 g Fmoc-Ser(tBu), 16.95 g HBTU, 11.95 g H-Tyr(tBu)-OAllyl and 26.10 ml DIPEA were reacted in a CYTOS® Lab System in anhydrous DMF at 45° C. and at a total flow rate of 32 ml/min at residence time of 1 min to yield 26.09 g crude material (yield based on HPLC: 96%) which was used in the next step without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08013117B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-41872591e3c84e609f9e4f162c97ea1c |
| Source note | uspto-grants-2011_09 |