Methanol → HCID 178499180, compound

HRID 907454Notes

Reaction equation

HRID 907454 reaction equation
S(Cl)(Cl)=O.[N+:5]([C:8]1[C:9]([C:13]([OH:15])=[O:14])=[N:10][NH:11][CH:12]=1)([O-:7])=[O:6].[CH3:16]O>>[CH3:16][O:14][C:13]([C:9]1[C:8]([N+:5]([O-:7])=[O:6])=[CH:12][NH:11][N:10]=1)=[O:15]

Participants

4

Reactant 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 178524956HCID 178524956, compound

Product 1

HCID 178499180HCID 178499180, compound

Procedure

Thionyl chloride (2.90 ml, 39.8 mmol) is slowly added to a mixture of 4-nitro-3-pyrazolecarboxylic acid (5.68 g, 36.2 mmol) in methanol (100 ml) at ambient temperature and the mixture is stirred for 48 hours. The mixture is reduced in vacuo and dried through azeotrope with toluene to afford the 4-nitro-1H-pyrazole-3-carboxylic acid methyl ester.

Workup

  1. dry with materialdried through azeotrope with toluene

Sources & evidence

ORD record
ord-9e9010c5872e44e38cf5d686a9195339
Source dataset
uspto-grants-2011_09
Patent number
US08013163B2

Reaction notes

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