HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl vinyl ketone → Methyl 3-[(3-oxobutyl)thio]propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl vinyl ketone | HCID 6570 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methyl 3-mercaptopropionate | HCID 18050 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Methyl 3-[(3-oxobutyl)thio]propanoate | HCID 11344502 | — |
Reaction Steps
Methyl vinyl ketone (90%, 185 ml, 2.0 mol) was added portionwise to a solution of methyl 3-mercaptopropionate (200 ml, 1.83 mol) and triethylamine (26 ml, 0.1 equiv) in THF (2.4 L). This mixture was heated slowly to 50 C and stirred at that temperature for 4.5 h. The solvent was then evaporated to afford 11 as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08013159B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-c1af50cae2dc449fb75bfad87ada9019 |
| Source note | uspto-grants-2011_09 |