Acetic Anhydride → 5,9-Bis(2,2,2-trifluoroethoxy)furo[3,4-g]quinoline-6,8-dione

Participants

Reaction Steps

A solution of 5,8-bis(2,2,2-trifluoroethoxy)quinoline-6,7-dicarboxylic acid 4 (180 mmol) in acetic anhydride (500 ml) was heated to reflux for 3 h and concentrated to dryness. The solid residue was triturated into 400 ml ether:hexane 1:4 to afford 68.2 g (96% yield for the last two steps) of the anhydride as a brownish solid.

Provenance & Evidence